Hope for Haley tells the story of Haley Thelen, a sweet and determined two-year-old living in the Pittsburgh area. Haley is diagnosed with Bosch-Boonstra-Schaaf Optic Atrophy Syndrome (BBSOAS). Haley's parents, Melissa and Jeff, detail the struggles living with disease from the perspectives of Haley and themselves, ultimately finding triumph in the situation through the NR2F1 foundation and through the many "inchstones" they see through Haley's journey.