Five of the most brilliant scientists of our time, gathered at the famous Institute for Advanced Study in Princeton, take us on their search for a groundbreaking discovery. They face an enormous challenge. Because how do you go beyond the existing frontiers of human knowledge? By becoming part of their world, we experience that a scientific breakthrough is not merely a light bulb-moment. It is a demanding process with emotional setbacks, anxiety and insecurities. But it is also driven by boundless ambition, truthfulness and unimaginable perseverance.